While it is old news now, about a month ago Adobe updated their accessible version of Digital Editions. You can read full details in a blog post from Adobe. According to Adobe, the main improvement is the ability to read continuously with a screen reader with this update.
I have had no success at getting this update to work on multiple computers with JAWS or NVDA. I’ve left comments with Adobe and exchanged email. Because of these problems, I’m not able to update my initial impressions of this application. I had hoped to provide an update as part of mentioning this update, which is why it has taken me a month to share news of the update here.